Principal Business Support Specialist

Join Immatics and Shape the Future of Cancer Immunotherapy

Immatics is committed to making a meaningful impact on the lives of patients with cancer. We are the global leader in precision targeting of PRAME, a target expressed in more than 50 cancers. Our cutting-edge science and robust clinical pipeline form the broadest PRAME franchise with the most PRAME indications and modalities, spanning TCR T-cell therapies and TCR bispecifics.

Why Join Our Commercial Team?

• Innovative Environment: Join the global leader in precision cancer immunotherapy and help drive the launch of our first PRAME-targeted therapy, anzu-cel. Your work will directly support a Commercial team at the forefront of scientific and clinical breakthroughs.

• Collaborative Culture: Work closely with senior Commercial leaders and cross-functional partners across Legal, Finance, Regulatory, and Medical Affairs. You'll be part of a diverse and agile team that values your initiative, discretion, and ability to enable team productivity and growth.

• Global Impact: Support a mission that extends far beyond the office. At Immatics, your expertise helps accelerate therapies that target more than 50 cancers, ultimately improving outcomes for patients worldwide.

Principal Business Support Specialist

We are seeking a Principal Business Support Specialist to provide executive and operational support to our US Commercial leadership team. This role blends the discretion of an Executive Assistant with the agility of a business operations coordinator, ensuring seamless operations, enabling team productivity, and supporting the buildout of the Commercial team and the launch of our first PRAME-targeted therapy, anzu-cel. This is a unique opportunity to work at the intersection of science, strategy, and execution, supporting a team driving transformative change in oncology.

FLSA Classification: Salary, Exempt Schedule: 8:00 AM – 5:00 PM; Monday to Friday Reports to: SVP, Commercial Location: Fully Remote

What You'll Do:

As a Principal Business Support Specialist, you will play a key role in supporting our Commercial operations:

• Executive & Administrative Support: Provide multi-faceted administrative support to ensure effective use of executive time and productive interactions with staff, partners, and external stakeholders.

• Manage complex calendars and proactively coordinate schedules, meetings, and travel across multiple time zones.

• Prepare agendas, briefings, presentations, and follow-up actions for internal and external meetings.

• Handle confidential information with discretion and serve as a trusted point of contact on behalf of the Commercial executives.

• Conduct research and information gathering on behalf of the SVP Commercial and leadership team; draft summaries, slides, and reports as needed.

• Commercial Business Support: Coordinate cross-functional projects, track deliverables, and manage team workflows using project management tools.

• Maintain and streamline shared Commercial resources such as templates, trackers, SOPs, and launch readiness tools.

• Implement and improve administrative processes to support the Commercial function's growth and scalability.

• Contribute to planning and execution of team events, off-sites, workshops, and key Commercial milestones.

• Organizational Relationship Management: Serve as an internal liaison between the Commercial team and key functions including Legal, Finance, Regulatory, and Medical Affairs.

• Build and maintain strategic working relationships across all levels of the organization to support seamless coordination and communication.

• Represent the Commercial function professionally and with a high degree of organizational knowledge.

Required Experience and Education:

• Bachelor's degree required. 4–7 years of experience supporting senior executives, preferably biotech. Prior experience supporting Commercial, Medical Affairs, Market Access, or Business Development teams is strongly preferred.

Preferred Experience and Education:

• Commercial launch support

• Oncology experience

• Cell Therapy experience

Competencies:

• Executive Support & Operations: Expert in managing complex calendars, travel, and meeting logistics.

• Maintains strict confidentiality and exercises sound judgment.

• Proactively supports workflows and improves administrative processes.

• Communication & Collaboration: Strong written and verbal communicator across all levels of the organization. Builds positive, strategic relationships with internal and external stakeholders. Represents the Commercial team with professionalism and discretion.

• Project & Organizational Agility: Coordinates multiple projects and deadlines with attention to detail. Comfortable using business tools (e.g., Microsoft 365, Teams, SharePoint). Quickly adapts to shifting priorities in a fast-paced biotech environment.

• Behavior & Mindset: Anticipates needs and takes initiative with minimal direction. Balances a calm, focused presence with a high standard for quality. Understands broader business goals and aligns support accordingly.

Work Environment:

This is a fully remote role based in a home-office setting, with team collaboration conducted through virtual tools and platforms. To support the demands of this position, the home work environment must be professional, quiet, and free from distractions, enabling focused, uninterrupted productivity. The remote setup is designed to foster effective communication, real-time collaboration, and seamless coordination using video conferencing tools. While offering the flexibility of working from home, the role requires a high level of personal accountability, responsiveness, and a reliable workspace that supports consistent, high-quality performance and engagement.

Travel required: up to 20% travel will be required.

Physical demands:

• Communicating Verbally: expressing or exchanging ideas by means of the spoken word to impart oral information to others to convey detailed spoken instructions or other workers accurately, loudly or quickly.

• Hearing: the ability to hear, understand, and distinguish speech and/or other sounds one-on-one, group or conference, telephone, and other sounds.

• Keyboarding: entering data or text into a computer or other machine by means of a keyboard. Devices include a traditional keyboard, 10 key-pad, touch screens and others.

• Lifting: raising or lowering an object (up to 25 lbs) from one level to another (includes upward pulling). Carrying is to transport an object – usually by holding it in the hands or arms but may occur on the shoulder.

• Near Visual Acuity: clarity of vision at approximately 20 inches or less (working with small objects, reading small print, including the use of computers).

• Pushing: Exerting force upon an object so that the object moves away from the object.

• Pulling: Exerting force upon an object so that the object moves toward the force.

• Sitting: remaining in a sitting position for at least 50% of the time.

• Standing/Walking: remain on one's feet in an upright position at a workstation.

• Stooping: occasional bending the body downward and forward by bending the spine at the waist - requiring full use of the lower extremities and back muscles.

Work authorization/security clearance requirements: Legal eligibility to work in the United States is required. Immatics participates in E-Verify and all new employees will be subject to the Department of Homeland Security requirements for employment.

Affirmative Action/EEO statement: Immatics is an equal opportunity employer. All employment decisions including the decision to hire, promote, discipline, or discharge, will be based on merit, competence, performance, and business needs. We do not discriminate