Scientist, Analytical Ops

Biologics Analytical Operations

At Gilead, we're creating a healthier world for all people. For more than 35 years, we've tackled diseases such as HIV, viral hepatitis, COVID-19 and cancer – working relentlessly to develop therapies that help improve lives and to ensure access to these therapies across the globe. We continue to fight against the world's biggest health challenges, and our mission requires collaboration, determination and a relentless drive to make a difference.

Every member of Gilead's team plays a critical role in the discovery and development of life-changing scientific innovations. Our employees are our greatest asset as we work to achieve our bold ambitions, and we're looking for the next wave of passionate and ambitious people ready to make a direct impact.

We believe every employee deserves a great leader. People Leaders are the cornerstone to the employee experience at Gilead and Kite. As a people leader now or in the future, you are the key driver in evolving our culture and creating an environment where every employee feels included, developed and empowered to fulfil their aspirations. Join Gilead and help create possible, together.

Key Responsibilities

• Support late-stage assay development by performing mass spectrometry to characterize molecules, degradation pathways, and define critical quality attributes in a phase-appropriate context.
• Contribute to analytical method development and qualification for protein characterization activities.
• Support comparability and stability studies using mass spectrometry.
• Operate, maintain, and troubleshoot Waters, Sciex, Agilent, Bruker QTOFs, and Thermo Orbitrap mass spectrometers.
• Collaborate with team members to develop advanced techniques for substance, assay, and tool characterization.
• Represent the Structure Characterization group in cross-functional project teams.
• Participate in technology transfer of assays from analytical development to QC and external CRO/CMOs.
• Coordinate analysis of in-process and product-related impurities for process comparability studies.
• Conduct scientific research to support drug candidate development and marketed drug research.
• Advise project teams on experiment planning and execution, considering economic, regulatory, and safety factors.
• Present experimental results, interpret data, and draw conclusions.
• Stay current with scientific literature and apply relevant knowledge to projects.
• Represent the company at national and international conferences.

Basic Qualifications

• BS degree with at least six (6) years of industry experience OR MS degree with at least four (4) years of industry experience.
• Strong knowledge of mass spectrometry, experimental design, and assay development.
• Excellent verbal, technical writing, and interpersonal communication skills.
• Ability to work independently and collaboratively in a matrixed environment.
• Strong organizational and planning skills.
• Proficient in Microsoft Office applications.

Preferred Qualifications

• PhD in Chemistry or a related discipline with limited industry experience.
• Familiarity with techniques such as:
• Peptide mapping by LC-MS/MS
• Intact mass analysis
• MS/MS for protein and carbohydrate structural elucidation/quantification
• Kinetic analyses
• Ultra-performance chromatography
• Proteolytic/chemical processing
• Knowledge of ICH guidelines and GMP.
• Expertise in mass spectrometry analysis software (Protein Metrics, Thermo BioPharma Finder, Skyline).
• Experience with data analysis and visualization tools (Python, R, JMP, Spotfire).
• Demonstrated ability to mentor junior team members and lead in cross-functional environments.