Staff AI Applications Engineer - Remote Eligible

Staff AI Applications Engineer

As a public and profitable company, we have ambitious plans to scale and enhance our AI-powered products and services. We're looking for software engineers who can work holistically to design strategic AI application solutions that go beyond just writing code. A strong track record in understanding business needs, communicating effectively, and delivering impactful AI-driven results is essential, along with leadership qualities to guide and inspire colleagues.

As a Staff AI Applications Engineer, you'll play a key role in advancing our AI technology platform and building intelligent software products that make a meaningful impact. You'll have the opportunity to lead large-scale technical efforts across multiple platforms that address our long-term AI strategy. You'll be expected to propose novel solutions to real-world business challenges using AI, work cross-functionally with engineering and non-engineering peers, and drive innovative solutions that enhance our user experiences through intelligent interfaces and workflows. The ideal candidate will also have a track record of being an effective thought leader and improving engineering best practices across the organization.

Job Responsibilities

• Design, develop, and maintain high-quality, full-stack AI-enabled software solutions that are scalable, reliable, and easy to maintain.
• Build data-intensive chat interfaces that effectively harness AI capabilities and provide exceptional user experiences.
• Develop provenance-aware form fills and intelligent summarization features that enhance productivity and accuracy.
• Create flexible, reusable frameworks for building AI-enabled applications that can be leveraged across the organization.
• Lead architecture and system design efforts for complex, distributed AI applications, ensuring alignment with long-term business and technical goals.
• Collaborate with cross-functional partners in product, design, and business teams to translate strategic AI initiatives into technical solutions.
• Mentor and coach engineers, fostering a culture of technical excellence, continuous learning, and knowledge sharing around AI application development.
• Champion engineering best practices and drive initiatives that improve system performance, code quality, and developer productivity across the organization.
• Be tech lead of a small squad of full stack engineers, providing technical direction, mentorship, and hands-on support.

Education, Experience, and Skills

• 8+ years experience in full-stack software development with a strong focus on modern web applications.
• Expert-level proficiency in TypeScript with extensive experience building production-grade front-end applications.
• Strong proficiency in Python for backend development, particularly in AI/ML integration contexts.
• 7+ years experience building large-scale front-end applications using React (highly preferred) or other modern frameworks (Vue, Angular).
• 7+ years experience developing back-end services and APIs in a distributed, service-oriented architecture using multiple paradigms (e.g. REST, RPC, GraphQL).
• Demonstrated experience building AI-powered user interfaces, including conversational interfaces and intelligent data processing workflows.
• Strong experience with data modeling using multiple database and storage types, particularly for AI application contexts.
• 5+ years experience designing and deploying resilient and scalable distributed services in the cloud using Docker and Kubernetes (e.g. AWS, GCP, Azure).
• Applied knowledge of multiple architectural paradigms and design patterns for AI applications.

Bonus Points For

• Experience with AI SDK, assistant-ui, or similar AI application typscript frameworks.
• Experience building document viewing and manipulation interfaces, particularly with PDFs.
• Prior healthcare / health tech experience, or experience in other regulated industries, particularly with data privacy and compliance requirements.
• Experience with LLM integration, prompt engineering, and RAG (Retrieval-Augmented Generation) architectures.
• Contributions to open-source AI application projects or frameworks.

Science - Minded, Patient - Focused.

At GeneDx, we create, follow, and are informed by cutting-edge science. With over 20 years of expertise in diagnosing rare disorders and diseases, and pioneering work in the identification of new disease-causing genes, our commitment to genetic disease detection, discovery, and diagnosis is based on sound science and is focused on enhancing patient care.

Experts in what matters most.

With hundreds of genetic counselors, MD/PhD scientists, and clinical and molecular genomics specialists on staff, we are the industry's genetic testing experts and proud of it. We share the same goal as healthcare providers, patients, and families: to provide clear, accurate, and meaningful answers we all can trust.

Sequencing has the power to solve diagnostic challenges.

From sequencing to reporting and beyond, our technical and clinical experts are providing guidance every step of the way:

Technical Expertise

• High-quality testing: Our laboratory is CLIA certified and CAP accredited and most of our tests are also New York State approved.
• Advanced detection: By interrogating genes for complex variants, we can identify the underlying causes of conditions that may otherwise be missed.

Clinical Expertise

• Thorough analysis: We classify variants according to our custom adaptation of the most recent guidelines. We then leverage our rich internal database for additional interpretation evidence.
• Customized care: Our experts review all test results and write reports in a clear, concise, and personalized way. We also include information for research studies in specific clinical situations.
• Impactful discovery: Our researchers continue working to find answers even after testing is complete. Through both internal research efforts and global collaborations, we have identified and published hundreds of new disease-gene relationships and developed novel tools for genomic data analysis. These efforts ultimately deliver more diagnostic findings to individuals.

Our Culture

At GeneDx, we are dedicated to cultivating an environment where creativity and innovation thrive. We believe in the power of community and collaboration, where diverse perspectives are embraced, and every voice contributes to our shared success. Our team is a vibrant mix of professionals who challenge and support each other in equal measure, fostering growth both personally and professionally. When you join us, you're not just taking on a job—you're joining a movement. A movement that champions curiosity, embraces change, and believes in making an impact, one patient at a time. Cultural principles we live by:

• Be bold in our vision & brave in our execution.
• Communicate directly, with empathy.
• Do what we say we're going to do.
• Be adaptable to change.
• Operate with a bias for action.

Benefits include:

• Paid Time Off (PTO)
• Health, Dental, Vision and Life insurance
• 401k Retirement Savings Plan
• Employee Discounts
• Voluntary benefits

GeneDx is an Equal Opportunity Employer. All privacy policy information can be found here.