Master Thesis Project – Affinity Protein Engineering

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Resin and Ligand Design is a department that belongs to the Resin and Technology and Filtration R&D. Typical products developed from the department are chromatography resins and other consumables used in BioPharma manufacturing.

Position Overview

We are now looking for a Master level applicant within the field molecular biotechnology. You will, as part of R&D in Solna, contribute to the development of disruptive products which are used in the manufacturing of leading biological drugs.

What You'll Do

This position is for the further development of anti-Z127 (Zhelper) affinity proteins. As Z127 as a fusion protein has shown itself to dramatically improve the expression and stability of ligands, platforms during selections and screening of new ligands would benefit by having Z127 fused throughout the development process to more accurately reflect final ligand characteristics and context. In addition, an anti-Z127 protein would allow for increased throughput and less downtime during screening and characterization of ligands. Libraries based on previous generations of anti-Z127 are to be selected and screened for increased affinity and alkaline stability. Hits derived will undergo further rational design and more detailed characterization.

This position utilizes techniques within the field of protein engineering and is suited for a student seeking to gain more experience in protein research and development.

Experimental work will include selections by phage display, and protein characterization by SPR, MS, LC, etc..

• Independently plan and accomplish given tasks, to reach given project objectives.
• Independently solve problems of "trouble shooting character" in project work.
• Document and report results both orally and in a written form.
• Conduct all tasks within the framework of Cytiva policies and guidelines.

Who You Are

• Master's student in Science or Engineering with a focus on chemistry, biochemistry, or biotechnology.
• Eligible for master thesis work between January 2026 – June 2026.
• Motivated and goal-oriented professional with strong interpersonal skills and a proactive approach to achieving results.
• Strong communicator with solid skills in both verbal and written reporting.
• Fluent in English and Swedish.

Join our winning team today. Together, we'll accelerate the real-life impact of tomorrow's science and technology. We partner with customers across the globe to help them solve their most complex challenges, architecting solutions that bring the power of science to life.