Postdoc In Chromatin And Neural Disorders

Postdoc In Chromatin And Neural Disorders

The Department of Biomedicine at Faculty of Health at Aarhus University invites applications for a position as Postdoc in the field of chromatin and neural disorders as per 1 December 2024 or as soon as possible thereafter. The position is a fixed-term full-time position for two years. Extension might be a possibility. The Department of Biomedicine prioritises diversity and a good work environment, as this is a prerequisite for groundbreaking research. In a diverse and international research environment, dedicated employees are looking to generate new knowledge within biomedical research areas such as infection and inflammation, membranes, neuroscience and personalised medicine. The Department of Biomedicine provides research-based teaching of the highest quality and is responsible for a large part of the medical degree programme. Academic staff contribute to the teaching. English is the preferred language in the laboratory, at meetings and at seminars. The department employs approx. 500 people from all over the world, and they make use of the department's modern laboratory-, core-, and animal facilities. The Department of Biomedicine focuses on innovation, entrepreneurship and collaboration with business and industry, and numerous researchers from the department have established companies to develop new medicinal treatments founded in professional scientific basic research.

This research project addresses the critical gap in experimental models for systematically investigating the function of risk factors in neurological disorders. By leveraging human-induced pluripotent stem cell (hiPSC) technology, we will establish hiPSC-derived brain cell models relevant to the study of neurodevelopmental disorders. These in vitro systems will be complemented by mouse models to provide a more comprehensive understanding of the disease mechanisms. We will focus on elucidating chromatin regulatory processes and the interconnected gene expression programs that drive neurodevelopment and contribute to neurodevelopmental disorders.

As Postdoc in Chromatin and Neural Disorders, your position is primarily research-based but may also involve teaching assignments. You will contribute to the development of the department through research of high international quality. In your daily work, you will work closely with colleagues on your project, where you will receive supervision and guidance. Your main tasks will consist of:

• Independent research of high international quality, including publication.
• Lead the development, optimization, and execution of stem cell-based brain cell differentiation, focusing on hiPSCs-derived neurons and microglia.
• Design and conduct in vivo experiments using mouse models for neurodevelopmental disorders and brain inflammation.
• Run spatial omics approach including multiplexed protein imaging and transcriptomics.
• Collect and analyze data from genome-wide sequencing, qPCR, Western blotting, and flow cytometry.
• Maintain detailed electronic records of experimental procedures, results, and analyses. Prepare reports, manuscripts, and presentations for both internal meetings and external scientific conferences.

You will report to Professor Kyung Min Noh. We are particularly interested in candidates who are familiar with studying epigenetic regulation in the neuronal system. You hold a PhD in Neuroscience, Neurobiology, Stem Cell Engineering, Biotechnology, or a related field. You have a solid background in histone modification and chromatin regulation, and you're experienced in working with human induced pluripotent stem cells (hiPSCs) and hiPSC-derived brain cell models. You're skilled in molecular biology techniques such as gene silencing and overexpression, qPCR, and flow cytometry, and you have experience working with mouse models. If you're familiar with omics technologies and/or bioinformatics, that's a definite advantage. You're able to lead research projects and collaborate across disciplines to drive innovation and reach scientific milestones. As a person, you have good interpersonal skills, are inclusive and team-oriented, and able to contribute to a good work environment. We expect you to be fluent in oral and written English.